Publications by authors named "V Stambolic"
β-catenin has influential roles affecting embryonic development, tissue homeostasis, and human diseases including cancer. Cellular β-catenin levels are exquisitely controlled by a variety of regulatory mechanisms. In the course of exploring the functions of the Nek10 tyrosine kinase, we observed that deletion of Nek10 in lung adenocarcinoma cells resulted in dramatic stabilization of β-catenin, suggestive of a Nek10 role in the control of β-catenin turnover.
View Article and Find Full Text PDFBreast cancer (BC) prognosis and outcome are adversely affected by obesity. Hyperinsulinemia, common in the obese state, is associated with higher risk of death and recurrence in BC. Up to 80% of BCs overexpress the insulin receptor (INSR), which correlates with worse prognosis.
View Article and Find Full Text PDFJCO Metformin has been associated with lower cancer risk in epidemiologic and preclinical research. In the MA.32 randomized adjuvant breast cancer trial, metformin ( placebo) did not affect invasive disease-free or overall survival.
View Article and Find Full Text PDFArticle Synopsis
- The extracellular matrix (ECM) collagen changes significantly during cancer development, but these changes are often overlooked in traditional cancer diagnostics, which typically use H&E staining.
- A new technique called polarimetric second-harmonic generation (P-SHG) microscopy allows for detailed imaging and analysis of collagen structures without the need for staining, providing more information about tissue characteristics.
- The study demonstrates that P-SHG microscopy can effectively differentiate between tumor and normal breast tissue, achieving high accuracy rates (94.2% accuracy) and suggesting it could be a valuable tool in cancer diagnostics and prognosis.
Importance: Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies.
Objective: To determine whether the administration of adjuvant metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes.
Design, Setting, And Participants: MA.