Climate-adaptive optimal water resources management: A multi-sectoral approach for the Munneru river basin, India.

Climate change profoundly affects water resource allocation by disrupting the availability, distribution, and quality of water across various regions. Optimal allocation of water resources represents a comprehensive strategy for water resource management by addressing the intricate connections between water allocation systems and their repercussions on the environment, society, and economy. In this study, an Optimal Water Resources Management (OWRM) framework was developed, focusing on the optimal allocation of water resources and crop planting structures across various sectors.

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics.

Introduction: Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence. Therapeutics targeting p70S6K1, a downstream member of this pathway, have recently gained importance due to its critical role in all types of breast cancer and its status as a prognostic marker.

A review of the influence of pH on toxicity testing of acidic environmental chemical pollutants in aquatic systems using zebrafish (Danio rerio) and glyphosate toxicity as a case study.

Glyphosate is an acidic herbicide reported to contaminate water sources around the globe. Glyphosate alters the pH of a solution depending upon the concentration and buffering capacity of the solution in which it is present. Hence, toxicity observed in laboratory-based studies could be caused by the chemical or acidic pH if the solution is not adjusted to neutral conditions, confounding toxicity assessments.