Synthesis, biological-pharmacological evaluation and molecular docking studies of Schiff base analogues of transition metal (II) complexes of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one.

Novel tridentate Schiff base [CuL], [NiL], [CoL], [MnL] and [ZnL] complexes have been prepared with Schiff base resulting from acetophenylidene-4-iminoantipyrine and tyrosine. Microanalytical data, IR, UV-vis, H, C-NMR, powder XRD, SEM, cyclic voltammetry, ESR, and mass spectral techniques confirmed the structural features of the chelates. The general formula of the complexes [ML] was confirmed from elemental analysis, mass and H-NMR spectral studies.

Synthesis, structural, pharmacological and molecular docking simulations studies of Schiff base transition metal complexes procured from acetylacetonyl-4-iminoantipyrine and tyrosine.

Schiff base complexes of Cu(II), Ni(II), Co(II), VO(II) and Zn(II) ions have been synthesized by condensation of acetylaceto-4-iminoantipyrine and tyrosine. The structural characterization of compounds has been investigated using elemental analysis, molar conductance and magnetic susceptibility measurements, UV-Vis., FT-IR, ESI-mass, H-NMR, C-NMR, ESR spectroscopy, cyclic voltammetry, XRD and SEM techniques.