Publications by authors named "V Soria"
Article Synopsis
- - The study aimed to find opportunities for improving antibiotic stewardship (AS) in medical-surgical intensive care units (MS-ICUs) and general wards (Gral-wards) across 41 hospitals in Latin America from March 2022 to February 2023.
- - Data was collected on antimicrobial use (AU) from 5780 MS-ICU and 7726 Gral-ward patients, revealing a 53.5% AU prevalence in MS-ICUs and 25.5% in Gral-wards, with a significant portion of antibiotics used for treating infections and surgical prophylaxis.
- - The study highlighted key areas for improvement in AU practices, including better antibiotic selection, the need for de
Lymphocyte-derived and lipoprotein-derived inflammatory ratios as biomarkers in bipolar disorder type I: Characteristics, predictive values, and influence of current psychopharmacological treatments.
Psychoneuroendocrinology
January 2025
Purpose Of This Research: The purpose of this research was to investigate peripheral inflammation by analyzing lymphocyte and lipoprotein-derived inflammatory ratios in patients with bipolar disorder type I (BD-I) and healthy controls (HCs), considering mood stabilizer drug treatments, sex and clinical trajectories.
Methods: This was a cross-sectional case-control study of BD-I patients (n=252) and healthy controls (n=62). We investigated peripheral inflammation biomarkers through blood count values (CBCs), lipoproteins and a complex panel of inflammatory ratios, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-HDL ratio (NHR), monocyte-to-HDL ratio (MHR), platelet-to-HDL ratio (PHR) and lymphocyte-to-HDL ratio (LHR).
Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease.
Span J Psychiatry Ment Health
July 2024
Article Synopsis
- Scientists studied how brain changes in older people could cause problems with thinking and feeling, particularly in those with mild cognitive issues and depression.
- They looked at 12 people with mild cognitive impairment, 24 people with late-life depression, and 26 healthy individuals using brain scans and tests over 2 years.
- The results showed that specific brain activity patterns could help doctors understand and spot early signs of thinking and mood problems that might lead to Alzheimer's disease.
Article Synopsis
- - Asciminib specifically targets the unique myristoyl pocket of BCR::ABL1, proving effective against chronic myeloid leukemia (CML) that has mutations resistant to other treatments, particularly in heavily pretreated patients.
- - In a phase I study of 48 patients with the T315I mutation, 62.2% reached a BCR::ABL1 level of ≤1% and nearly 49% achieved a major molecular response, demonstrating significant antileukemic activity over a two-year period.
- - Common severe side effects included increased lipase and low platelet counts, but the overall risk-benefit profile supports asciminib as a viable treatment for T315I-mutated CML-CP
Effective connectivity of the locus coeruleus in patients with late-life Major Depressive Disorder or mild cognitive impairment.
Span J Psychiatry Ment Health
March 2024
Introduction: We compared effective connectivity from the locus coeruleus (LC) during the resting-state in patients with late-life Major Depressive Disorder (MDD), individuals with amnestic Mild Cognitive Impairment (aMCI), and Healthy Controls (HCs).
Participants: 23 patients with late-life MDD, 22 patients with aMCI, and 28 HCs.
Material And Methods: Participants were assessed in two time-points, 2 years apart.