Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities.

Background: Methyl aminolaevulinate-photodynamic therapy (MAL-PDT) is an effective treatment in facial/scalp actinic keratosis (AK).

Objectives: The aims of this study were to compare efficacy, safety, cosmetic outcome and patient preference of MAL-PDT vs. cryotherapy in patients with AK at other locations.

Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients.

Background: Adapalene is a new naphthoic acid derivative developed for the topical treatment of acne vulgaris.

Objective: We describe the results of a combined safety analysis of two multicenter trials conducted in the U.S.

Skin tolerance of adapalene 0.1% gel in combination with other topical antiacne treatments.

Background: Adapalene (Differin gel) is a new naphthoic acid derivative developed for the topical treatment of acne vulgaris.

Objective: We assessed, in healthy volunteers, the skin irritancy potential of three combinations, each including adapalene 0.1% gel and one topical marketed antiacne product.

Split-face comparison of adapalene 0.1% gel and tretinoin 0.025% gel in acne patients.

Background: Adapalene is a new naphthoic acid derivative developed for the topical treatment of acne vulgaris.

Objective: We compared the skin tolerance of adapalene 0.1% gel with tretinoin 0.

Adapalene 0.1% gel has low skin-irritation potential.

Background: Adapalene is a new naphthoic acid derivative with potent retinoid and antiinflammatory properties, developed for the topical treatment of acne vulgaris.

Objective: We compare the cutaneous safety of adapalene in different gel vehicles with tretinoin 0.025% gel.