Publications by authors named "V Sood"
Frailty in children with chronic liver disease: Prevalence and impact on outcomes.
J Pediatr Gastroenterol Nutr
December 2024
Objectives: Frailty is a well-known complication of chronic liver disease and has been recognized as a poor prognostic factor in cirrhotic patients being associated with increased morbidity and mortality. There is limited available pediatric literature in this regard. The current study aimed to estimate the prevalence of frailty and analyze the predictive factors and their association with long-term outcomes in children with liver disease.
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- Hypoglycemia can signal inborn metabolic errors, often seen in patients with liver issues, but there's no agreed-upon definition or diagnostic method.
- The text presents four pediatric cases of different ages who showed hypoglycemia as their main symptom.
- It also offers a systematic diagnostic guide for better identifying inherited metabolic liver diseases linked to hypoglycemia.
Mutations in doublecortin domain-containing protein 2 (DCDC2) lead to neonatal sclerosing cholangitis (NSC), and portal hypertension (PHTN). The objective of the study was to systematically evaluate PHTN, variceal bleeding, and outcomes of patients with DCDC2-related NSC. The study included children with homozygous or compound heterozygous variants in DCDC2.
View Article and Find Full Text PDFEpicardial Lead Performance Trends in Pediatric and Congenital Heart Disease.
World J Pediatr Congenit Heart Surg
November 2024
Article Synopsis
- Epicardial pacing systems are preferred for small pediatric patients and those with complex congenital heart disease, as transvenous access isn't feasible.
- Although epicardial leads have higher failure rates compared to transvenous leads, limited data exists on their performance immediately after implantation.
- In this study, most epicardial leads with high initial thresholds improved to acceptable levels by the first postoperative day, indicating that lead performance generally gets better shortly after surgery.
The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system.
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