PET Imaging in Chimeric Antigen Receptor T-Cell Trafficking.

The evolving field of chimeric antigen receptor (CAR) T-cell therapy, though promising, necessitates more comprehensive imaging methods to enhance therapeutic effectiveness and track cell trafficking in patients and ex vivo. This review examines the application of PET imaging in CAR T-cell trafficking and optimizing their therapeutic impact. The application of PET imaging using various radiotracers is promising in providing evaluation of CAR T-cell interaction within the host, thereby facilitating strategies for improved patient outcomes.

Physiological Imaging Methods for Evaluating Response to Immunotherapies in Glioblastomas.

Glioblastoma (GBM) is the most malignant brain tumor in adults, with a dismal prognosis despite aggressive multi-modal therapy. Immunotherapy is currently being evaluated as an alternate treatment modality for recurrent GBMs in clinical trials. These immunotherapeutic approaches harness the patient's immune response to fight and eliminate tumor cells.

Study of formulation of pharmaceutical solution form of paracetamol in the pediatric clinical practice.

Unlabelled: AIM of the study was selection of 2 different formulations of paracetamol of 2.5% (125 mg/5 mL) in the Pediatric practice. Paracetamol is widely used in the form of the syrup, with usual percentage of acting ingredient of 125 mg/5 mL.

Development ontogenesis of receptor tracheobronchial system in isolated preparations of pigs trachea in vitro.

Flow research of the development of receptor bronchial system was conducted in this work since the first day in 4th week of extra-uterine life, by following reactions of isolated tracheal rings in acetylcholine (Ach), histamine (Hist), and prostaglandin (PGF2-alfa) in concentrations of: 10(-4), 10(-3), 10(-2), 10(-1), mol/dm3, at piggy's of ages: 1 day, 1 week, 2 weeks and 4 weeks. Results shows that Ach causes reaction of smooth muscles since the first day of extra-uterine life in a significant way (p < 0.01).