Therapeutic Monitoring of Vancomycin Implemented by Eremomycin ELISA.

Background/objectives: Due to a narrow therapeutic window, side-effects, toxicities, and individual pharmacokinetics (PK) variability, WHO classifies vancomycin (VCM) as a "watch antibiotic" whose use should be monitored to improve clinical effectiveness. Availability and ease of use have made the immunoassay technique the basic tool for the therapeutic drug monitoring (TDM) of VCM concentrations.

Methods: The present study describes the development of a TDM tool for VCM based on anti-eremomycin (ERM) antibody enzyme-linked immunosorbent assay (ELISA).

Production of antibody and development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of eravacycline.

Eravacycline (ERC) was approved for clinical use in 2018. It is more potent than other tetracyclines and can overcome resistance, making it an attractive option for combating multidrug-resistant bacterial infections. Intensive pharmacokinetic (PK) studies are currently being conducted to ensure the effectiveness and safety of ERC in various groups of patients, including those undergoing extracorporeal therapies.

[Health schools for patients with chronic cardiac insufficiency (innovative technologies)].

Modern programs for the management of patients with chronic cardiac insufficiency (CCI) envisage systemic preventive measures aimed to extend their information support, stimulate compliance, optimize feedback, modify lifestyle, and facilitate social adaptation. Traditional health schools for CCI patients as a form of secondary prophylaxis helps to achieve the above goals even though efficiency of this work needs to be further improved. Results of regular medical examination of 417 patients with CCI (294 women and 123 men) visiting local outpatient facilities in 2008 were analysed.

Excited states of the helium-antihydrogen system.

Potential energy curves for excited leptonic states of the helium-antihydrogen system are calculated within the Ritz variational approach. An explicitly correlated ansatz for the leptonic wave function is employed describing accurately the motion of the leptons (two electrons and positron) in the field of the helium nucleus and of the antiproton with an arbitrary orbital angular momentum projection Lambda onto the internuclear axis. Results for Lambda=0, 1, and 30 are presented.

Potential energy curves for excited states of the hydrogen-antihydrogen system.

The potential energy curves for the hydrogen-antihydrogen (HH) system in states with a leptonic orbital angular momentum projection Lambda=0, 1, 2, 6, and 30 are presented. Within the framework of the adiabatic picture, explicitly correlated Gaussians are used as basis functions which describe accurately the hydrogen-antihydrogen interaction. The critical internuclear distances where the system transforms into positronium and protonium atoms are found.