Publications by authors named "V Shamala"
Article Synopsis
- The CTLA-4 gene helps regulate immune responses by suppressing T-cell activity to prevent autoimmunity and is expressed on activated T-cells, with its mRNA producing a soluble form (sCTLA-4) that circulates in the blood.
- A study using qPCR and HRMA found a significant link between the CTLA-4 genetic variant (rs3087243 SNP G/G genotype) and Rheumatoid Arthritis (RA) in an Indian population.
- Patients with the G/G genotype had lower levels of sCTLA-4 and a higher risk of RA, suggesting that mutations in the CTLA-4 gene may lead to overactive T-cells and contribute to the disease.
Cytoplasmic T Lymphocyte Antigen-4 (CTLA-4) gene encodes for a glycoprotein, expressed on activated T-cells to transfer an inhibitory signal to control T-cell activation and proliferation. Techniques coupled with Real-time Polymerase Chain Reaction (PCR) and High-Resolution Melting Analysis (HRMA) were used to screen a missense signal peptide polymorphism (CTLA-4 + 49 A/G rs231775) in the Indian population to detect its association with Rheumatoid Arthritis (RA). Further, the resulting outcome was confirmed by Sanger's sequencing technique, and genotype frequencies were calculated.
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