Publications by authors named "V Shakthivel"
Invasive breast cancer (IBC) is a significant health concern globally, contributing to substantial morbidity and mortality among women. Dysregulated cellular proliferation, a hallmark of malignancy, involves molecular pathways modulated by proteins such as cyclin D1 and p16. Understanding their roles in IBC pathogenesis and their association with prognostic parameters is crucial for refining treatment strategies.
View Article and Find Full Text PDFArticle Synopsis
- - Lung cancer is the top cause of cancer deaths worldwide, making early diagnosis vital, and the 2023 WHO reporting system aims to standardize the criteria for diagnosing lung cytopathology to enhance accuracy.
- - A study analyzed 207 cytology samples from patients aged 27 to 87, categorizing them into five WHO categories, with significant findings about the risk of malignancy associated with each category.
- - The results showed a high sensitivity of 84.75% and a negative predictive value of 74.29% when considering certain categories as positive for malignancy, indicating that the WHO system could improve diagnostic consistency and patient management, though further research is needed.
Article Synopsis
- The study compares the diagnostic accuracy of two systems, the Modified Masood Scoring Index (MMSI) and the International Academy of Cytology (IAC) Yokohama System, for classifying breast fine needle aspirates.
- It evaluates the risk of malignancy (ROM) for various categories, with findings showing that the MMSI has certain limitations, particularly in correlating with the IAC categories.
- Results indicate that the Yokohama system offers better sensitivity, specificity, and overall accuracy in categorizing breast lesions, suggesting it is a more effective method for such assessments.