Publications by authors named "V Sexl"
A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extracellular matrix (ECM). During fibrogenesis, distinct genes become reactivated specifically in fibroblasts, e.
View Article and Find Full Text PDFDespite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research when looking for targeted therapies. We discovered cyclin C as a key factor for B-ALL development and maintenance.
View Article and Find Full Text PDFProtein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease-associated kinases using the high sensitivity of the kinase conformation (KinCon) reporter system.
View Article and Find Full Text PDFArticle Synopsis
- Innate lymphoid cells (ILCs) play a crucial role in how the gut adapts to low oxygen levels, particularly under conditions like inflammation and colitis.
- The HIF-1α subunit is important for defining the ILC phenotype during acute colitis, but its effects on these cells during chronic conditions, such as inflammatory bowel disease, are still unclear.
- In mice lacking HIF-1α in NKp46+ ILCs during chronic colitis, researchers noted fewer ILC1s but more neutrophils and macrophages, suggesting HIF-1α helps regulate inflammation and prevents damage like fibrosis in the intestines.