Publications by authors named "V Scaglione"

Almost 25 years have now passed since the first identification of (). It can cause infections both in immunocompetent and immunocompromised hosts. However, it has been rarely described as an aetiology of infectious endocarditis.

View Article and Find Full Text PDF

Objective: Sleep disorders (SD) are prevalent in people with HIV (PWH), but poorly addressed in HIV care. We evaluated the effectiveness of a multidimensional program for SD in an outpatient HIV clinic.

Methods: Interventional study in 175 PWH on ART suffering from insomnia.

View Article and Find Full Text PDF

Background: Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) decreased mortality and hospital admissions in high-risk patients with mild to moderate COVID-19. Nevertheless, there is a lack of data about the pharmacoeconomic impact of these antivirals in the Omicron era. We conducted a pharmacoeconomic analysis assessing the medical costs of the use of these antivirals compared to those occurred in people who refused the treatment.

View Article and Find Full Text PDF

Carnitine O-acetyltransferase (CRAT) is a crucial enzyme involved in mitochondrial energy metabolism. Alterations in CRAT activity have emerged as significant contributors to the pathogenesis of Leigh syndrome and related mitochondrial disorders. In this study we employed an integrated approach combining in silico docking analysis and virtual screening of chemical libraries with subsequent in vitro validation to identify small molecule modulators of the activity of the wild type (WT) CRAT and the p.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explored the effectiveness of early combination treatment (an antiviral plus a monoclonal antibody) versus monotherapy in severely immunocompromised patients with COVID-19.
  • - After evaluating 81 patients, the combination therapy did not significantly reduce mortality or hospitalization rates compared to monotherapy, but it did improve emergency department access.
  • - The findings suggest that early combination therapy may have a positive impact on overall clinical outcomes; however, more research is required to confirm these results.
View Article and Find Full Text PDF