Improvement of Russian clinical guidelines and reduction of mortality in perforated ulcers.

Objective: To analyze the results of laparoscopic surgery in patients with perforated ulcers using evidence-based medicine approaches.

Material And Methods: We compared the efficacy and effectiveness of laparoscopic and open surgeries in patients with perforated ulcers. Meta-analysis of mortality after laparoscopic surgeries (randomized controlled trials) and trial sequential analysis were carried out.

Is antipsychotic augmentation associated with improved functioning in patients on clozapine?

Objective: We aimed at exploring the relationship between functional outcomes in patients on clozapine augmented with antipsychotics in treatment-resistant schizophrenia using standard outcome measures Health of Nation Outcome Scales (HoNOS) and Life Skills Profile (LSP-16).

Method: In a cross-sectional study of 83 patients on clozapine treated in a psychiatric rehabilitation hospital, the association between the primary outcome measure, LSP-16 including its subscales, and treatment with antipsychotic augmentation (AA) were analysed using linear regression.

Result: The presence of moderate-to-severe positive symptoms on the HoNOS 6 dichotomised item measure was the only statistically significant predictor of functional impairment as determined by total LSP-16 score.

Does theta burst stimulation have differential benefit for those with melancholic or non-melancholic depression?

Background: To determine if theta burst stimulation (TBS) is of preferential benefit to those with melancholic or non-melancholic depression as an adjunctive treatment for treatment resistant depression (TRD).

Methods: Fifty-two patients receiving TBS at a private psychiatric hospital participated in a naturalistic study. Four diagnostic strategies were used to assign melancholic versus non-melancholic depression subtype status.

[Prospects for development of laparoscopic surgery in the Central Federal District of the Russian Federation].

Objective: To analyze the achievements of laparoscopic surgery in the Central Federal District of Russia and outline perspective trends for further application.

Material And Methods: The study included adult patients with abdominal surgical diseases hospitalized in general surgical departments of the Central Federal District between 2014 and 2021. We analyzed the prevalence of elective and emergency laparoscopic surgeries.