Publications by authors named "V Saurit"
Article Synopsis
- The study aimed to investigate how smoking exposure is linked to organ damage in patients with systemic lupus erythematosus (SLE) using a specific damage score (SLICC-SDI) in an Argentinian cohort.
- Out of 623 SLE patients analyzed, 84% were non-smokers, while 16% were current smokers, with 17% showing severe organ damage (SLICC-SDI ≥3).
- The findings indicated that current smoking, older age, longer disease duration, and the use of cyclophosphamide are significantly associated with severe organ damage in SLE patients.
Objectives: To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.
Methods: The first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization.
Article Synopsis
- A patient with mevalonate kinase deficiency (MKD), an autoinflammatory disease, displayed two gene variants linked to the condition and suffered from recurrent periodic fevers and multiple organ symptoms, particularly a form of kidney disease called IgA nephropathy.
- Despite various immunosuppressive treatments over seven years, the patient found effective relief only after starting canakinumab, a medication targeting inflammation.
- Complications arose from a severe kidney event after an infection, raising questions about how MKD-related inflammation might interact with kidney disease, suggesting a possible connection between the patient's symptoms and underlying disease processes.
Article Synopsis
- - The study investigates the characteristics and effects of the time taken to diagnose systemic lupus erythematosus (SLE) in a Latin American cohort, noting that diagnosis can often be delayed and that SLE may resemble other diseases.
- - Patients with longer diagnosis times (over 6 months) were often older, female, of Mestizo descent, uninsured, and displayed atypical symptoms, but this delayed diagnosis did not seem to affect their disease progression or mortality rates significantly.
- - Overall, the research concludes that within this cohort, waiting up to 24 months for an SLE diagnosis, with a median of 6 months, did not lead to worse health outcomes.
Factors Associated With Mortality in Patients With Immune-Mediated Rheumatic Diseases and COVID-19 From Latin America: Data From Argentina, Mexico, and Brazil.
J Clin Rheumatol
January 2024
Objective: To describe characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with rheumatic immune-mediated inflammatory diseases (IMIDs) from Argentina, Mexico and Brazil, and to assess factors associated with mortality in this population.
Methods: Data from 3 national registries, SAR-COVID (Argentina), CMR-COVID (Mexico), and ReumaCoV-Brasil (Brazil), were combined. Adult patients with IMIDs and SARS-CoV-2 infection were recruited.