Publications by authors named "V Sarayova"
Article Synopsis
- The study investigates the effects of long-term hypogonadism, starting from puberty, on aging male rats, focusing on body composition, bone density, and physical measurements.
- Results indicated that while long-term hypogonadism did not significantly change body weight, it led to increased fat mass (26% higher), decreased lean mass (44% lower), shorter body size, and reduced bone mineral density (13% lower) compared to control males.
- These findings suggest that long-term hypogonadism may better reflect the health issues of aging males, such as sarcopenic obesity and osteoporosis, compared to studies using short-term hypogonadism in younger animals.
Neonatal life is a sensitive period of brain plasticity. There are concerns that pre-weaning handling may therefore alter behavioural phenotype in adolescence or adulthood. Since neurodevelopment tests require daily manipulation with pups, later behavioural outcomes might be biased by repeated handling during suckling period.
View Article and Find Full Text PDFThermal processing of foods at temperatures > 100 °C introduces considerable amounts of advanced glycation end-products (AGEs) into the diet. Maternal dietary exposure might affect the offspring early development and behavioral phenotype in later life. In a rat model, we examined the influence of maternal (F0) dietary challenge with AGEs-rich diet (AGE-RD) during puberty, pregnancy and lactation on early development, a manifestation of physiological reflexes, and behavioral phenotype of F1 and F2 offspring.
View Article and Find Full Text PDF