Publications by authors named "V Santosh"
Article Synopsis
- Researchers found a long noncoding RNA called RIM28 that inhibits the tumor suppressor p53 in glioblastoma (GBM) and glioma stem-like cells (GSC), leading to worse cancer outcomes.
- This RNA interacts with a specific mRNA that increases TRIM28 protein, which in turn decreases p53 levels through enhanced ubiquitination, reducing the effectiveness of p53's DNA damage response.
- Silencing RIM28 suppressed GSC growth and reduced glioma tumors, while its overexpression promoted tumor growth and resistance to the chemotherapy drug Temozolomide, suggesting it could be a potential therapeutic target for GBM treatments.
Background/aim: Glioblastomas (GBM) are infiltrative malignant brain tumors which mostly recur within a year's time following surgical resection and chemo-radiation therapy. Studies on glioblastoma cells following radio-chemotherapy, have been demonstrated to induce trans-differentiation, cellular plasticity, activation of DNA damage response and stemness. As glioblastomas are heterogenous tumors that develop treatment resistance and plasticity, we investigated if there exist genome-wide DNA methylation changes in recurrent tumors.
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- - Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a new type of brain tumor mainly affecting children, characterized by specific imaging and histological features, often presenting with seizures.
- - In a study of 15 diagnosed cases, imaging revealed well-defined solid-cystic tumors with calcifications, and histopathology showed a mix of tumor cell types that were immunopositive for CD34.
- - Molecular analysis detected mutations consistent with PLNTY, including BRAF and FGFR2/3 gene alterations, indicating it should be considered as a potential diagnosis for similar tumors, particularly in younger patients with seizure histories.
Introduction: Diffuse midline glioma (DMG) is a relatively new entity which was introduced in the fourth edition of the WHO classification of CNS tumours in 2016 and later underwent revision in 2021. It is an infiltrative glioma arising from midline structures, viz., thalamus, spine, and brainstem.
View Article and Find Full Text PDFProspective Study to Evaluate the Role of Dual Point Contrast-enhanced Magnetic Resonance Imaging in Differentiation of Brain Tumoral from Nontumoral Tissue: A Magnetic Resonance/PET Study.
Indian J Nucl Med
May 2024
Background And Purpose: Follow-up imaging of gliomas is crucial to look for residual or recurrence and to differentiate them from nontumoral tissue. Positron emission tomography (PET)-magnetic resonance imaging (MRI) is the problem-solving tool in such cases. We investigated the role of dual point contrast (DPC)-enhanced MRI to discriminate tumoral from the nontumoral tissue compared to PET-MRI taken as the gold standard.
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