Publications by authors named "V Saeidi"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment but pose risks for severe skin reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which need more study.
- This systematic review examined 158 cases to analyze factors related to SJS/TEN in ICI patients to improve risk assessment and clinical management.
- Findings show that SJS/TEN typically occurs in older males, often linked to PD-1 inhibitors, and highlights significant morbidity and mortality risks, though limitations exist in the data reporting and consistency.
Background: Impaired immunity may drive the increased incidence and aggression of cutaneous squamous cell carcinoma (cSCC) in patients with hematologic malignancy; however, precise mechanisms and prognostic biomarkers remain undefined. CD73 maintains elevated immunosuppressive adenosine levels and is associated with poor prognosis in several tumor microenvironments.
Objective: Identify poor outcome biomarkers in patients with cSCC and hematologic malignancy.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerative painful lesions with violaceous undermined borders. Up to 75% of PG cases develop in association with an underlying systemic disease. Monoclonal gammopathy is reportedly a concomitant condition with PG, with studies indicating immunoglobulin (Ig) A gammopathy as the most common.
View Article and Find Full Text PDFEvaluation and monitoring of pemphigus vulgaris (PV) typically involve autoantibody detection by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). We aimed to determine the levels of antipemphigus immunoglobulin (Ig) G autoantibodies using ELISA and IIF (as standard biomarkers), and compare it to prolactin, macrophage migration inhibitory factor (MIF), and C-reactive protein (CRP) (as nonstandard biomarkers) to determine which of these non-standard biomarkers is appropriate for PV monitoring. The experiment was performed before and during therapy.
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