Glycyrrhizic Acid Mitigates Haloperidol-Induced Neurotoxicity in SHSY-5Y Cells and Rats Via Activation of PI3k/Akt/Nrf2 Pathways.

Antipsychotic medications are used to treat a psychological condition called 'Schizophrenia'. However, its long-term administration causes irregular involuntary motor movements, targeting the orofacial regions. Glycyrrhizic acid (GA) is a naturally occurring triterpene saponin glycoside obtained from the roots of the Glycyrrhiza glabra (liquorice) plant and well known for its antioxidant, antiapoptotic and neuroprotective abilities.

Biomarkers.

Background: Neuropeptides are crucial proteins in the central nervous system, which significantly influence neurophysiological processes. This analysis explores cerebrospinal fluid alterations in Alzheimer's disease, offering insights to better understand the condition and explore novel diagnostic and therapeutic avenues.

Method: We systematically searched MEDLINE (PubMed), EMBASE, Cochrane, and Scopus using specific search strategies.

Biomarkers.

Background: Emerging studies suggest the interaction of the gut microbiome with physical and cognitive function. However, it remains unknown whether the same microbiome is linked with both functions and/or if they are unique.

Method: Utilizing data and samples from the Microbiome in Aging Gut and Brain (MiaGB) Consortium cohort, we assessed the whole genome gut microbiome metagenomics in 113 older adults (mean age 72 years [39 male and 74 female]) with high and low physical functions (measured using Short Physical Performance Battery [SPPB]) and cognitive function (measure using Montreal Cognitive Assessment [MoCA]).

Biomarkers.

Background: The microbiota-immune-brain axis is implicated in Alzheimer's disease. Alterations in gut microbiota and immune functions in mild cognitive impairment (MCI) are inconsistent and remain to be understood. This study aims to investigate immune cell phenotyping and its link with gut microbial composition associated with cognitive function.

Oxidative toxicity mediated oophoritis alters ovarian growth in Channa punctatus under prolonged exposure to herbicide, paraquat dichloride.

Herbicide paraquat dichloride, a potent redox agent found its way to natural water bodies and influences their health; however, its impact on the reproductive health of fish is potentially less studied and requires clear investigation. This study was conducted to elucidate its effect on the gonadal health of female fish, Channa punctatus over 60 days. The 96-h LC of test herbicide was calculated as 0.