Publications by authors named "V Saada"

As a promising alternative to bone marrow aspiration (BMA), mutational profiling on blood-derived circulating cell-free tumor DNA (cfDNA) is a harmless and simple technique to monitor molecular response and treatment resistance of patients with refractory/relapsed multiple myeloma (R/R MM). We evaluated the sensitivity and specificity of cfDNA compared to BMA CD138 positive myeloma plasma cells (PCs) in a series of 45 R/R MM patients using the 29-gene targeted panel (AmpliSeq) NGS. , , , , and were the most frequently mutated genes.

View Article and Find Full Text PDF

Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 inflammasome are cellular host factors required for SARS-CoV-2 infection. Lung autopsies from patients with severe coronavirus disease 2019 (COVID-19) reveal that NLRP3 expression is increased in host cellular targets of SARS-CoV-2 including alveolar macrophages, type II pneumocytes and syncytia arising from the fusion of infected macrophages, thus suggesting a potential role of NLRP3 and associated signaling pathways to both inflammation and viral replication.

View Article and Find Full Text PDF
Article Synopsis
  • A 38-year-old woman with a rare bone disease had a fluid buildup in her chest and was found to have a type of cancer called promyelocytic sarcoma.
  • This type of cancer can be hard to diagnose because it doesn’t always show typical signs, especially in patients with bone diseases.
  • The good news is that she was treated successfully with a special therapy using two medicines, and she was doing better three months later!
View Article and Find Full Text PDF
Article Synopsis
  • There are strict laws for clinical research, but many authors and editors don't always follow them correctly.
  • An investigation looked at 456 studies from a hospital in France and found lots of problems with how they reported their ethics approvals.
  • Researchers want better checks from scientific editors and publishers to make sure that ethical rules are followed in research.
View Article and Find Full Text PDF