Publications by authors named "V SKOP"
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlorinated paraffins (SCCPs) has been restricted since 2017, the use of medium-chain chlorinated paraffins (MCCPs) has risen as their replacement. Due to lipophilic character, it can be expected that CPs enter the cells; however, the in vitro accumulation potential of CPs remains poorly understood.
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- The study highlights that in mice, nearly 40% of the light phase and 80% of the dark phase are marked by periods of increased energy expenditure (EE), known as ultradian bouts.
- These bouts are associated with higher body temperatures and consist of most physical activity and wakefulness, suggesting that they are more indicative of mouse physiology than the traditional light/dark cycles.
- The findings indicate that these ultradian bouts, resulting from brain-driven increases in body temperature, lead to significant energy expenditure from various bodily activities, making mouse metabolic physiology largely episodic rather than solely reliant on circadian rhythms.
While phosphodiesterase-5 inhibition (PED5i) may prevent hypertrophy and failure in pressure-overloaded heart in an experimental model, the impact of PDE5i on volume-overload (VO)-induced hypertrophy is unknown. It is also unclear whether the hypertrophied right ventricle (RV) and left ventricle (LV) differ in their responsiveness to long-term PDE5i and if this therapy affects renal function. The goal of this study was to elucidate the effect of PDE5i treatment in VO due to aorto-caval fistula (ACF) and to compare PDE5i treatment with standard heart failure (HF) therapy with angiotensin-converting enzyme inhibitor (ACEi).
View Article and Find Full Text PDFObjective: Physical activity is a major component of total energy expenditure (TEE) that exhibits extreme variability in mice. Our objective was to construct a general, physiology-based model of TEE to accurately quantify the energy cost of physical activity.
Methods: Spontaneous home cage physical activity, body temperature, TEE, and energy intake were measured with frequent sampling.
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activity, improves glucose tolerance and reduces body weight with most pronounced reduction of visceral adipose tissue due to reduced food intake, suppressed adipogenesis and elimination of senescent cells.
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