Sonogenetics is a novel antiarrhythmic mechanism.

Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic mechanism proposed here focuses ultrasound on a cardiac tissue, controls endogenous stretch-activated Piezo1 ion channels on the focal region's cardiomyocyte sarcolemma, and restores normal heart rhythm.

Photon-Scanning Approach to Control Spiral Wave Dynamics in the Heart.

Self-organizing spiral electrical waves are produced in the heart during fatal cardiac arrhythmias. Controlling these waves is therefore an essential step in managing the disease. Here we present an effective method for controlling cardiac spiral waves using optogenetics.

[Multidisciplinary consensus on the use of Cereton drug in treatment of central nervous system diseases with cognitive impairments of congenital and acquired origin in children. Resolution of the multidisciplinary panel of experts].

Interdisciplinary consensus on the use of Cereton in the treatment of central nervous system diseases with cognitive impairment of congenital and acquired genesis in children. Resolution of the interdisciplinary council of expertsXXIII All-Russian Forum "Zdravnitsa-2024".

[Diagnosis, pathogenesis and treatment of attention deficiency syndrome].

Attention deficit hyperactivity disorder is the dominant form of cognitive and behavioral dysfunctions in childhood, the disease has a chronic course and manifests in adolescents and adults in 50-80% of cases. An adequate diagnosis is the testing of parents and teachers using the Conners questionnaire in two stages, the second is mandatory after 6 months to confirm the persistence of symptoms over time. The pathogenesis is based on violations of mediation of dopamine and norepinephrine in the fronto-striate-thalamic system, responsible for the function of constant attention, caused by molecular genetic mechanisms.

[Epileptic syndromes associated with focal clonic seizures].

Objective: To study clinical, electroencephalographic and neuroimaging features in children with epileptic syndromes associated with focal clonic seizures (FCS).

Material And Methods: We examined 1258 patients with various forms of epilepsy with the onset of seizures from the first day of life to 18 years.

Results: FCS was identified in 263 patients (20.