[The physical and chemical properties of the skin and the action of therapeutic physical factors].

This article discusses the importance of the physical and chemical properties of the skin subjected to the action of the therapeutic physical factors. The author presents the data illustrating the influence of alterations in skin permeability on the penetration of medicinal substances into the organs and tissues of the body under conditions of application of various physico-pharmacological methods based on the use of chemical ingredients of peloid therapy and other balneotherapeutic technologies. The effectiveness of skin permeability is known to be of special importance in the context of physical therapy since it determines the action of its individual components.

[Skin receptors and therapeutic physical factors].

This review presents the data on the receptor function of the skin and its role in the formation of the body's response to the action of physical therapy. Especially much attention is given in the paper to the influence of ultrasound, microwaves, laser radiation, various medical environments, and other physical factors on the morphofunctional condition of the skin receptors. Possible mechanisms of changes in receptor activity under effects of physical therapeutic factors are analyzed.

[Combined physical therapy: general information, interaction between physical factors].

The present article is devoted to problems pertaining to the combined (simultaneous) medical application of the therapeutic physical factors. The classification of the methods used in combined physical therapy is proposed, their advantages over the traditional therapeutic modalities are discussed, the general principles of simultaneous application of the medical physical factors are considered. The possible variants of interaction between such physical factors in the case of their combined application are theoretically determined, the criteria for their quantitative assessment (coefficients of synergism and effectiveness of combination) are offered, examples of their application for the evaluation of the efficiency of the selected combinations are provided.

Suppression of Ehrlich carcinoma growth by cobra venom factor.

Cobra venom factor (CVF) depletes the complement system of the blood by forming stable convertase C3/C5 of the alternative pathway. We found that CVF from the Thailand cobra venom slows down the growth of subcutaneous Ehrlich carcinoma (EC) in mice at a dose of 1.7 nmol/g.

The Effects of Repetitive Transcranial Magnetic Stimulation on Picrotoxin-Induced Convulsions in Mice.

Background: Clinical and experimental results show that repetitive transcranial magnetic stimulation (rTMS) is effective and safe in the treatment of epilepsy. The characteristics of the impulse magnetic field (IMF) are empirical in these studies, making impossible to compare their effectiveness.

Objectives: The article presents the results of a study of the anticonvulsive effects of different modes of IMF on the picrotoxin seizure model, which is important for studying GABAergic brain mechanisms activated by rTMS.