[Humoral autoimmune reactions directed against autoantigens of the H-2 histocompatibility system in mice with developing Rauscher leukemia].

Antibodies exhibiting a selective anti-H-2 haplotype reaction with thymic and splenic lymphocytes of intact mice were found in the sera of mice of the strains BALB/c, C57Bl/6, AKR and BDF1 with the developing Rauscher leukemia by applying the membrane immunofluorescent and complement-dependent cytotoxicity techniques in vitro. Monoclonal antibodies against H-2 IAd and H-2 IAk and sorption tests using lymphocytes of the congenic-resistant strains as target cells were used to show that the aforementioned antibodies acted against autoantigens which are the products of the genes of the I-subregion of the H-2 histocompatibility complex.