The effect of pumpkin seeds snack on inhibitors and promoters of urolithiasis in Thai adolescents.

Supplementation of basal mixture or pumpkin seeds snack gave a higher level of inhibitor of crystal formation or aggregation than the control period. Moreover, pumpkin seeds snack showed inhibition effect to a greater extent than basal mixture. In the light of this study, it is suggested that pumpkin seeds snack, a high nutritive mixture, is satisfactory to improve the nutrients and increase the level of inhibitors of crystal formation or aggregation which will subsequently reduce the risk of bladder stone disease in Thailand.

The influence of pre- and postnatal caloric intake on colon carcinogenesis.

Mother rats were allowed to litter under conventional conditions. They were fed a complete, semipurified diet during gestation, and at time of littering the numbers of pups were reduced to either eight per litter or four per litter in two additional groups. At weaning, all rats were continued on the same diet that their mothers had consumed.

Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline.

A dietary deficiency of methyl donors, the lipotropes methionine and choline, enhances the activity of hepatocarcinogens in rodents. To determine if the reverse is true, an excess of dietary choline, methionine, or both was fed to male mice given a carcinogenic dose of aflatoxin B1 (AFB1). Fifty weeks following the last dose of AFB1, all survivors were killed then examined for tumor incidence, and samples of nontumorous liver tissue were assayed for activities of mixed function oxidases (MFO).