[Drinks other than water for the prevention and metaphylaxis of urolithiasis].

Low hydration is a leading risk factor for the formation of any type of urinary stones. The most common recommendation for prevention of urolithiasis is to increase the fluid intake as a way to increase daily diuresis and prevent supersaturation of urine with stone-forming substances. The fluid is consumed not only with drinking and mineral water, but also with other beverages, including citrus and various fruit juices, coffee, tea, wine and beer, which contain not only a liquid, but also a chemicals, nutrients and microelements that can affect its composition and play a significant role in changing the risk of stone formation.

[What water is recommended for the primary and secondary prevention of urolithiasis?].

The literature review dedicated to a problem of using various types of water for the primary and secondary prevention of urolithiasis is presented. According to the one of the oldest hypotheses, water with different characteristics may contribute to urinary stone formation. The role of hard or soft water in the development of kidney stones is still controversial.

TERT Promoter Mutations Increase Tumor Aggressiveness by Altering TERT mRNA Splicing in Papillary Thyroid Carcinoma.

Context: Telomerase reverse transcriptase promoter (TERT-p) mutations, which upregulate TERT expression, are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). TERT expression is also observed in a proportion of PTCs without TERT-p mutations, but such tumors show less aggressiveness and better prognosis than TERT-p mutation-positive tumors.

Objective: TERT has multiple splicing variants whose relationships with the TERT-p status and clinicopathological characteristics remain poorly understood.

Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors.

Introduction: The radioiodine-refractory (RAI-R) recurrent papillary thyroid carcinomas (PTCs) are more frequent in elderly patients and have an unfavorable prognosis. Data on the prevalence and characteristics of RAI-R recurrent PTCs in patients of young and middle age with or without a history of radiation exposure in childhood are poorly described. The aim of the current study was: i) to determine the frequency of RAI-R recurrent PTCs among donors of the Chornobyl Tissue Bank (CTB) and analyze the clinicopathological features of primary tumors (PTs), primary metastases (PMTSs), recurrent metastases (RMTSs) and risk factors for RMTS, and ii) to determine the immune checkpoint status (ICS) of the RAI-R recurrent PTCs and to assess the factors associated with ICS positivity.

Radiation-Related Thyroid Cancer.

Radiation is an environmental factor that elevates the risk of developing thyroid cancer. Actual and possible scenarios of exposures to external and internal radiation are multiple and diverse. This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures.