Publications by authors named "V S Nunes"
Objective: This study compared the outcomes of two cohorts of patients with coronavirus disease 2019 (COVID-19) who received COVID-19 convalescent plasma transfusions between 2020 and 2021.
Methods: This retrospective study was conducted at a tertiary hospital in São Paulo, Brazil. We included a retrospective cohort of patients who received convalescent compassionate plasma, and another group of patients from a previous clinical study.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that acts on both innate and adaptive immunity, fostering immune escape in tumors and contributing to cancer progression. Despite the lack of definitive markers for immunophenotyping MDSCs, particularly the polymorphonuclear (PMN-MDSC) subset, these cells seem to play a crucial role in acute myeloid leukemia (AML) patients' prognosis. Additionally, the maturation stage of MDSCs remains a subject of debate and is largely unknown within the AML context.
View Article and Find Full Text PDFObjectives: To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.
Methods: This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).
Results: TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level.
Importance: International guidelines lack consistency in their recommendations regarding routine imaging in the follow-up after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). Consequently, follow-up strategies differ between centers worldwide.
Objective: To compare clinical outcomes, including recurrence-focused treatment and survival, in patients with PDAC recurrence who received symptomatic follow-up or routine imaging after pancreatic resection in international centers affiliated with the European-African Hepato-Pancreato-Biliary Association (E-AHPBA).
Article Synopsis
- Leukotriene B4 (LTB) is an inflammatory mediator derived from arachidonic acid, acting through the BLT1 receptor, while resolvins E1 and E2, which promote resolution of inflammation, come from omega-3 fatty acids like EPA.
- Long-term molecular dynamics simulations were used to explore how LTB and resolvins E1 and E2 activate the BLT1 receptor, focusing on receptor dynamics, electrostatic interactions, and binding affinity.
- Results indicated that both LTB and RvE1 maintain the BLT1 receptor in an active state, highlighting key residues like H94, R156, and R267 that play significant roles in the interaction, with findings aligning well with previous experimental data