Reimagining community engagement in TB elimination: a perspective from the field.

The role of community engagement (CE) in TB policy, care provision and research has been recognized as important, but most models of CE put communities at the periphery of these activities. In this Editorial, written by TB-impacted community members and care providers, we explore the meaning of CE and current barriers to its implementation. We present a model of CE that places community members at the center of TB policy, care provision and research.

Characterizing Patients with ypT0N1 Gastric Adenocarcinoma Within the AJCC Staging System.

Introduction: The standard of care for gastric cancer in the United States involves perioperative chemotherapy. While most post-therapy pathologic staging results are concordant (i.e.

Lymphocyte Activation Gene 3 Expression, γδ T-Cell/Major Histocompatibility Complex Class I Interactions, and Prognosis in Merkel Cell Carcinoma.

Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a poor prognosis. One of the major mechanisms of immune evasion in MCC involves downregulation of major histocompatibility complex class I (MHC-I). Anti-PD-1/programmed death ligand 1 checkpoint inhibitors have revolutionized treatment for MCC, producing objective responses in approximately 50% of patients, and are now the standard of care; however, a substantial proportion of patients either fail to respond or develop resistance to checkpoint inhibitors.