Preparing a Liposome-Aided Drug Delivery System: The Entrapment and Release Profiles of Doxorubicin and 9-(-Piperazinyl)-5-methyl-12()-quino [3,4-b][1,4]benzothiazinium Chloride with Human Serum Albumin.

The principal aim of this work was to prepare a liposomal drug delivery system based on the commercial drug doxorubicin (DOX) and a budding agent with promising anticancer activity, 9-(-piperazinyl)-5-methyl-12()-quino [3,4-b][1,4]benzothiazinium chloride (9-PBThACl). : A spectrophotometric methodology was used to meticulously investigate the drug entrapment and release characteristics of the new liposomal complexes (L) based on dipalmitoylphosphatidylcholine (DPPC) with human serum albumin (HSA) and its defeated analog (dHSA). : The impact of the operational parameters (temperature and pH) on the liposome/drug(s)/(d)HSA, namely [L ]:(d)HSA] systems, as well as the polarity of the phospholipid bilayer, was examined.

Synthesis and Structure of 5-Methyl-9-(trifluoromethyl)-12-quino[3,4-][1,4]benzothiazinium Chloride as Anticancer Agent.

In this work, the synthesis, structural analysis and anticancer properties of 5-methyl-9-trifluoromethyl-12-quino[3,4-][1,4]benzothiazinium chloride () are described. Compound was synthesized by reacting 1-methyl-4-butylthio-3-(benzoylthio)quinolinium chloride with 4-(trifluoromethyl)aniline, respectively. The structure of the resulting product was determined using H-NMR and C-NMR spectroscopy as well as HR-MS spectrometry.

Characterization of neurocognitive deficits in patients with post-COVID-19 syndrome: persistence, patients' complaints, and clinical predictors.

Introduction: Cognitive symptoms persisting beyond 3 months following COVID-19 present a considerable disease burden. We aimed to establish a domain-specific cognitive profile of post-COVID-19 syndrome (PCS). We examined the deficits' persistence, relationships with subjective cognitive complaints, and clinical variables, to identify the most relevant cognitive deficits and their predictors.

Towards Anticancer and Antibacterial Agents: Design and Synthesis of 1,2,3-Triazol-quinobenzothiazine Derivatives.

In this paper, we describe a new method for synthesizing hybrid combinations of 1,2,3-triazoles with a tetracyclic quinobenzothiazinium system. The developed approach allowed for the production of a series of new azaphenothiazine derivatives with the 1,2,3-triazole system in different positions of the benzene ring. In practice, the methodology consists of the reaction of triazole aniline derivatives with thioquinanthrenediinium -chloride.