[Structural-metabolic changes in neurons of hippocampus and neocortex under the influence of "polydan"].

The aim of this work was to study the influence of different regimens of polydan administration on the structural and metabolic state of neurons of rat hippocampus and neocortex. The animals of experimental groups were administered 75 mg/kg of polydan intraperitoneally once or 5 times. Animals of control groups received similar injections of sodium chloride isotonic solution.

Effect of polidan on ultrastructural changes in the cerebral cortex and hippocampus of rats.

Electron microscopy and morphometry of neurons in layer V of the somatosensory area in the neocortex and CA3 field in the dorsal hippocampus showed that single and 5-fold intraperitoneal injection of Polidan was followed by ultrastructural and metabolic changes in neurons reflecting activation of protein synthesis. The number of free ribosomes decreased; the number of polysomes and count of ribosomes in polysomes and tubules of the granular endoplasmic reticulum increased. Study of mitochondria and neuropil showed that Polidan activates synthetic processes in the neocortex and hippocampus.