[Combined low-intensity laser radiation in renal tuberculosis].

Combined external radiation in the projection of the kidneys and intravascular laser blood radiation by applying an AZOR-2K apparatus were used in the combined treatment of 54 patients with tuberculosis of the urinary system. Analysis of the biochemical and immunological parameters of the patients' peripheral blood before and 3 weeks and 3 months after the combined treatment provided evidence suggesting a decrease in the magnitude of lipid peroxidation, an increase in the antioxidative status, and a reduction in the level of metabolites that affect on the development of the intoxication syndrome. The clinical findings suggest that the combined treatment has a beneficial impact on the course of renal tuberculosis, as appeared as better functional indices of urinary organs.

Initiation and inhibition of free radical processes in H2O2-metmyoglobin (methemoglobin)-2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) systems.

Rates of free radical initiation were determined at 20 degrees C in 10 mM phosphate buffer (pH 7.4) in the systems metmyoglobin (methemoglobin)-H2O2 using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) as the diammonium salt (ABTS). The catalytic activity of MetMb was 2-3-fold higher than that of MetHb.

[The role of investigating the fractional composition of high-density cholesterol lipoproteins and dys-alpha-lipoproteinemia for detection of atherogenic disorders].

Disorders of cholesterol-acceptor and cholesterol-transporting properties of antiatherogenic lipoproteins are associated with changes in etherification and fractional composition of high-density lipoprotein (HDLP) cholesterol. The said metabolic shifts prompted us to develop a new method for assessment of the cholesterol coefficient of plasma lipoprotein spectrum atherogenicity calculated by the formula: (CS--alpha-CS)/alpha-CS.(ECS/FCS), where alpha-CS, ECS, and FCS are total, ether-bound, and free HDLP cholesterols, respectively.

[Lipid metabolism and atherogenesis in tuberculosis in experimental animals].

As shown in experiments on intact rabbits (60), rabbits with experimental tuberculosis (20), experimental atherosclerosis (30) and atherosclerosis concurrent with tuberculosis (35), disorders in lipid metabolism in pulmonary and combined affections follow the same pattern. This presents with atherogenic dysalpha- and dyslipoproteinemia, high levels of free cholesterol in the lipid phase of atherogenic lipoproteins, increased red cell ratio cholesterol/phospholipids, red cell enrichment with not easily oxidized phospholipids, activation of free radical oxidation of plasma and red cell lipids. Tuberculosis promotes lipoidosis formation making worse its development.

[Characteristics of disorders of lipid peroxidation homeostasis and immunologic indicators in patients with chronic respiratory diseases working in chemical industry].

A total of 151 individuals was examined, among which 40 were apparently healthy, 28 have had recurrent respiratory diseases and in 83 the chronic obstructive pulmonary disease was proven. The results demonstrated the intensified lipids peroxidation, endogenic antioxidants deficiency and the depressed T and B immunity in those exposed to the occupational chemical hazards, especially with concurrent acute and chronic respiratory diseases. The levels of diene conjugates, fat-soluble vitamins, T lymphocytes subunits and serum immune complexes were proved to serve as the criteria of premorbid condition in the humans exposed to occupational hazards.