Publications by authors named "V S Iakovleva"
Background: Bibrachial amyotrophy associated with an extradural CSF collection and infratentorial superficial siderosis (SS) are rare conditions that may occasionally mimic ALS. Both disorders are assumed to be due to dural tears.
Case Presentation: A 53-year-old man presented with a 7-year history of slowly progressive asymmetric bibrachial amyotrophy.
Article Synopsis
- The liver can regenerate, but chronic damage can exhaust this ability, causing fibrotic tissue buildup and serious disease.
- Researchers conducted a genetic screen and found that lowering levels of Microfibril associated protein 4 (Mfap4) in liver cells boosts their proliferation and helps reduce liver damage.
- Targeting Mfap4 influences important liver regeneration pathways, suggesting the potential for siRNA-based treatments to improve liver healing.
Oncofetal transcription factor SALL4 is essential for cancer cell survival. Recently, several groups reported that immunomodulatory imide drugs (IMiDs) could degrade SALL4 in a proteasome-dependent manner. Intriguingly, we observed that IMiDs had no effect on SALL4-positive cancer cells.
View Article and Find Full Text PDFUnlabelled: Unfortunately, available liver cancer treatments are associated with modest survival advantage. The biggest factor improving survival is early detection, but the current understanding of early transformation events is limited. Therefore, we set up a model to study these early events and investigated the relationship of premalignant, senescent hepatocytes, a regenerative environment, and the influence of secreted factors on liver tumorigenesis.
View Article and Find Full Text PDFBackground And Purpose: To investigate the relationship between the functional connectivity (FC) of the sensorimotor and cognitive cerebellum and measures of structural damage in patients with multiple sclerosis (MS) and no physical disability.
Methods: We selected 144 relapsing-remitting MS patients with an Expanded Disability Status Scale score of ≤1.5 and 98 healthy controls from the Italian Neuroimaging Network Initiative database.