Publications by authors named "V S Govindarajan"
Naringin-templated magnetic molecularly imprinted polymers for selective quercetin extraction from onion peel.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2024
Article Synopsis
- A Magnetic Molecularly Imprinted Polymer (MMIP) was created using naringin as a template molecule and acrylamide as a functional monomer, utilizing ultrasound to enhance its ability to adsorb naringin.
- Surprisingly, the MMIP showed a stronger affinity for quercetin than for its intended target, naringin, leading to further studies on its adsorption properties and kinetics.
- The research led to a maximum adsorption capacity of 7.2 mg/g for quercetin and 4.9 mg/g for naringin, and quercetin was successfully quantified from onion peel waste using the MMIP combined with HPLC-UV technology.
Article Synopsis
- The Fontan operation is a procedure for patients with a single ventricle heart condition, historically improved to enhance patient outcomes and minimize complications, but concerns exist regarding the proper sizing of extracardiac conduits.
- A study aimed to evaluate the effects of upsizing these conduits using advanced imaging and fluid dynamics to find optimal sizes for improving blood flow and reducing complications.
- Results showed that upsizing conduits led to significant reductions in power loss (16%-63%), pressure gradients (15%-35%), and variations in local flow dynamics, emphasizing the necessity of personalized treatment strategies for better hemodynamic outcomes.
Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune responses and sensitize solid tumors to immunotherapy including colorectal cancer, melanoma, and clear renal cell carcinoma. Here, we found that targeting a novel, master epigenetic regulator, Zinc Finger Protein 638 (ZNF638), induces viral mimicry in glioblastoma (GBM) preclinical models and potentiates immune checkpoint inhibition (ICI).
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- * The connection between fibrinogen and neurotransmitters like serotonin suggests that fibrinogen could play a role in mood regulation, with its interaction with astrocytes potentially leading to nerve fiber damage, contributing to depressive symptoms.
- * There's potential for therapeutic strategies targeting fibrinogen, such as adjusting PAI-1 activity or blocking its interaction with brain cells, but more research is needed to understand the complexities of fibrinogen's role in mood disorders
Aortic lesions, exemplified by bicuspid aortic valves (BAVs), can complicate congenital heart defects, particularly in Turner syndrome patients. The combination of BAV, dilated ascending aorta, and an elongated aortic arch presents complex hemodynamics, requiring detailed analysis for tailored treatment strategies. While current clinical decision-making relies on imaging modalities offering limited biomechanical insights, integrating high-performance computing and fluid-structure interaction algorithms with patient data enables comprehensive evaluation of diseased anatomy and planned intervention.
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