Publications by authors named "V S Gorrepati"
Article Synopsis
- Opioid-induced esophageal dysfunction (OIED), which includes spastic esophageal disorders (SEDs) and esophagogastric junction outflow obstruction (EGJOO), is the focus of a study that compares treatment outcomes of peroral endoscopic myotomy (POEM) between opioid users and nonusers.
- The study involved a matched analysis of 128 patients (64 opioid users and 64 nonusers) who underwent POEM, ensuring that demographic and clinical characteristics were comparable.
- Results showed that opioid users had a significantly lower clinical response to POEM (79.7% vs. 93.8%), with higher daily opioid doses linked to a greater likelihood of treatment failure.
Common genetic variants located in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials with Calcium Channel Blocker (CCB) medication improved mood stability for some BD patients. We hypothesize that manic patients who carried calcium channel risk variants would differentially benefit from treatment with CCBs.
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