Publications by authors named "V S Dedkov"
The widespread use of the oral poliovaccine from Sabin strains (tOPV) radically reduced poliomyelitis incidence worldwide. However, OPV became a source of neurovirulent vaccine-derived polioviruses (VDPVs). Currently, circulating type 2 VDPVs (cVDPV2) are the leading cause of poliomyelitis.
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- - Dugbe virus (DUGV), a tick-borne virus first identified in Nigeria in 1964, has been found in several African countries and was notably detected in Senegal during the 1970s and 1980s.
- - Recent research detected three new DUGV isolates from 2877 ticks collected in the Kolda region of Senegal, indicating continued viral presence and potential unnoticed transmission in the area.
- - Phylogenetic analysis shows these new isolates are related to earlier DUGV strains in West Africa, and the study established a cost-effective method for full-genome sequencing using nanopore technology, revealing a low mutation rate and stable evolution of the virus.
Based on the success of the Sabin2-based vaccine, a next-generation nOPV2 poliovirus vaccine has been developed. For epidemic monitoring and conducting epidemiological investigations, it is necessary to have a diagnostic assay with the ability to differentiate this variant from others. Here we describe such a real-time RT-PCR assay.
View Article and Find Full Text PDFThe COVID-19 pandemic has become a serious challenge for humanity almost everywhere globally. Despite active vaccination around the world, the incidence proportion in different countries varies significantly as of May 2022. The reason may be a combination of demographic, immunological, and epidemiological factors.
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