Publications by authors named "V Rouach"
-chronic graft vs. host disease (cGVHD) is associated with substantial morbidity and mortality. We aimed to analyze advances in treatment strategy and outcomes during the last decade due to the incorporation of novel immunosuppressive therapy (IST) drugs in the armamentarium.
View Article and Find Full Text PDFUnlabelled: We studied the association between non-osteoporotic fractures and future major osteoporotic fractures, using UK health records. Non-osteoporotic fractures were found to increase the risk of major osteoporotic fractures, although to a lesser extent than osteoporotic fractures. This highlights the importance of considering all previous fractures in assessing future fracture risk.
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- Anabolic treatment is necessary for high-risk osteoporosis patients, but the current injectable medications are not well-accepted; this study tests a new oral PTH tablet alternative.
- In a 6-month, double-blind study with 161 postmenopausal women, the oral PTH showed dose-dependent effects on bone markers, with the highest dose (2.5 mg) significantly increasing bone formation markers and decreasing bone resorption markers.
- The 2.5 mg oral PTH tablets improved bone mineral density (BMD) at crucial sites (lumbar spine, total hip, and femoral neck) compared to placebo, and while some mild side effects occurred, no serious adverse events were reported.
Purpose: This pilot study aimed to explore the feasibility of scanning the human distal radius bone marrow in vivo to detect osteoporosis-related changes using magnetic resonance and evaluate whether the radius may serve as an accessible probing site for osteoporosis. This may lead in the future to the use of affordable means such as low-field MRI scanners for the monitoring of disease progression.
Methods: A clinical trial was performed using a 3T MR scanner, including 26 women assigned into three study groups: healthy-premenopausal ( = 7; mean age 48.