Publications by authors named "V Rosen"
Our ability to pinpoint causal variants using GWAS is dependent on understanding the dynamic epigenomic and epistatic context of each associated locus. Being the best studied skeletal locus, associates with many diseases and has a complex cis-regulatory architecture. We interrogate regulatory interactions and model disease variants and .
View Article and Find Full Text PDFThe pain assessment in animals is challenging as they cannot verbally express the site and severity of pain. In this study, we tried a small implantable actimeter, "Nanotag", to monitor spontaneous locomotor activity and body temperature in animals suffering from a chemical-induced rat knee arthritis as compared to naïve and steroid-treated rats. Nanotag could detect the decrease in locomotor activity quickly after the arthritis induction and anti-inflammation analgesic treatment by intra-articular injection of steroid significantly improved locomotor activity.
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- X-linked hypophosphatemia (XLH) results from mutations in the PHEX gene, leading to bone issues like rickets and enthesopathy in adults, which causes pain and movement difficulties.
- In mice models of XLH, increased bone morphogenetic protein (BMP) and Indian hedgehog (IHH) signaling were found to play a significant role in the development of enthesopathy; blocking BMP signaling with palovarotene showed a reduction in these signals.
- The study also highlights that while growth/differentiation factor 5 (GDF5) isn't crucial for BMP/IHH signaling in normal entheses, its inappropriate activity in XLH contributes to enthesopathy, suggesting that targeting G
The Great Masquerade: Not All Coronary Artery Stenosis Are Created Equal.
Methodist Debakey Cardiovasc J
May 2024
Article Synopsis
- A 60-year-old male with a history of smoking and cocaine use presented with worsening chest pain, prompting cardiac imaging.
- Imaging results showed fluctuating stenosis in the left main artery, suggesting a possible case of vasospasm, which was confirmed after treatment with intracoronary nitroglycerin.
- This case underscores the often-misdiagnosed condition of vasospastic angina (VA), emphasizing the need for awareness in diagnosis and management strategies.
Secondary lymphedema occurs in up to 20% of patients after lymphadenectomy performed for the surgical management of tumors involving the breast, prostate, uterus, and skin. Patients develop progressive edema of the affected extremity due to retention of protein-rich lymphatic fluid. Despite compression therapy, patients progress to chronic lymphedema in which noncompressible fibrosis and adipose tissue are deposited within the extremity.
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