Publications by authors named "V Roldan Schilling"
Article Synopsis
- A study referred to as SUPRATOL investigated the effects of transoral laser microsurgery for supraglottic laryngectomy, comparing its outcomes for swallowing and quality of life to traditional open surgery, revealing similar oncologic results but limited data on swallowing rehabilitation and QoL before this trial.
- The trial included 102 patients across 26 hospitals in Germany, with the main goal of measuring aspiration-free swallowing after one year and exploring various related factors such as tracheostomy needs and overall survival.
- Results showed high rates of aspiration-free swallowing at the 12-month mark, with a majority of patients still managing well with swallowing, although some required tracheostomy and PEG tube interventions, indicating mixed results on QoL
Objectives: To analyze the clinical profile, adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation (AF), taking rivaroxaban in clinical practice.
Methods: Observational and non-interventional study that included AF adults recruited from 79 Spanish centers, anticoagulated with rivaroxaban ≥ 6 months before being included. Data were analyzed according to age (≥ 80 .
Article Synopsis
- The species discussed is significant in healthcare-associated infections and has developed resistance, particularly to carbapenems, but research on its colonization and virulence mechanisms is limited compared to other species.* -
- The study identifies the type 3 fimbria in some Chilean isolates, which plays a key role in the bacteria's ability to adhere to surfaces and cells, with mutants lacking the fimbria exhibiting reduced adhesion.* -
- While the type 3 fimbria is not commonly found (5.94-7.37% occurrence) across all variants, it appears in some strains associated with infections, suggesting its potential importance in the survival and fitness of certain subtypes.*
Using Progress Feedback to Enhance Treatment Outcomes: A Narrative Review.
Adm Policy Ment Health
January 2025
Article Synopsis
- There is a growing need for better access to effective mental health services, including telehealth, but outcomes in routine clinical practice are often lower than those in controlled trials.
- Progress feedback, which involves ongoing monitoring of patient treatment responses, is an underused evidence-based practice that could enhance treatment effectiveness.
- Recent reviews indicate that integrating feedback into various mental health interventions shows small to medium improvements, particularly for common mental health issues, and suggests that advanced technology and clinical tools can further strengthen its impact.
Objective: Assess if MEK inhibitor blockade of RAS-ERK pathway adaptive response in high grade serous ovarian cancers (HGSOC) improves platinum sensitivity.
Methods: Three HGSOC cell lines and three patient derived organoid (PDOs) samples from ascites of platinum resistant HGSOC patients were collected. Cell lines and PDOs were exposed to carboplatin and MEK inhibitors cobimetinib or trametinib.