Optimal cerebral perfusion pressure during induced hypertension and its impact on delayed cerebral infarction and functional outcome after subarachnoid hemorrhage.

Disturbed cerebral autoregulation (CA) increases the dependency of cerebral blood flow (CBF) on cerebral perfusion pressure (CPP). Thus, induced hypertension (IHT) is used to prevent secondary ischemic events. The pressure reactivity index (PRx) assesses CA and can determine the optimal CPP (CPPopt).

Leucencephalopathy in Patients with Parkinson's Disease and Deep Brain Stimulation.

Background: Leucencephalopathy (LE) is often detected on magnetic resonance imaging in elderly patients. These white matter lesions may interfere with lead trajectories for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) and are associated with complications after DBS surgery.

Objective: This study was conducted to assess the incidence of LE in PD patients and to evaluate correlations with complications after DBS surgery.

Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics.

Objectives: Subarachnoid hemorrhage (SAH) may critically impair cardiovascular, metabolic, and gastrointestinal function. Previous research has demonstrated compromised drug absorption in this group of patients. This study aimed to examine the impact of SAH on gastrointestinal function and its subsequent effect on the absorption of enterally administered drugs, using esomeprazole as a probe drug.

Logistic organ dysfunction system as an early risk stratification tool after aneurysmal subarachnoid hemorrhage.

Aneurysmal subarachnoid hemorrhage (aSAH) not only causes neurological deficits but also influences extracerebral organ functions. The Logistic Organ Dysfunction System (LODS) reliably captures organ dysfunctions and predicts mortality of critically ill patients. This study investigated LODS in the setting of aSAH as a surrogate marker for early brain injury (EBI).