Antioxidant Active Phytochemicals in Explained by Aquaporin Mechanisms.

The antioxidant action of terngymnoside C () and hydroxytyrosol-1-glucoside (), isolated for the first time from the flower buds of , as well as katsumadin (), obtained from the seedless fruits, was evaluated using ABTS and HO- models. In silico docking analysis of , , and determined their affinity forces to the aquaporin monomers of the modeled protein 3 (AQP3) and human protein 7 (AQP7) channels that regulate the HO cell transport. The ABTS antiradical capacity of these compounds showed IC values of 22.

Ligand-Based Drug Design of Genipin Derivatives with Cytotoxic Activity against HeLa Cell Line: A Structural and Theoretical Study.

Cervical cancer is a malignant neoplastic disease, mainly associated to HPV infection, with high mortality rates. Among natural products, iridoids have shown different biological activities, including cytotoxic and antitumor effects, in different cancer cell types. Geniposide and its aglycone Genipin have been assessed against different types of cancer.

Spatiotemporal defocus sensitivity function of the human visual system.

Tunable lenses make it possible to measure visual sensitivity to rapid changes in optical power, surpassing the limits imposed by mechanical elements. Using a tunable lens system, we measured, for the first time, the spatiotemporal defocus sensitivity function (STDSF), and the limits of human defocus perception. Specifically, we measured defocus sensitivity using a QUEST adaptive psychophysical procedure for different stimuli (Gabor patches of different spatial frequencies, natural images, and edges) and we developed descriptive models of defocus perception.

Defocus flicker of chromatic stimuli deactivates accommodation.

Tunable lenses, optical elements able to change their optical power within milliseconds, constitute an emerging technology increasingly used in ophthalmic applications. In this study, 25 subjects looked through tunable lenses at a chromatic stimulus to evaluate the perceptual response of the human visual system to periodic changes in defocus of 0.25D of amplitude and 15 Hz of temporal frequency.