Publications by authors named "V Rispoli"
Cerebral Amyloid-β Deposition, Axial Features, and Cognitive Alterations in Patients with Parkinson's Disease Treated with Bilateral STN-DBS: A Long-Term Cohort Study.
J Pers Med
December 2024
Our aim was to evaluate the possible long-term cerebral deposition of amyloid-β in patients with PD treated with subthalamic nucleus deep brain stimulation (STN-DBS) and its possible influence on axial and cognitive variables. Consecutive PD patients treated with bilateral STN-DBS with a long-term follow-up were included. The amyloid-β deposition was evaluated postoperatively through an 18F-flutemetamol positron emission tomography (PET) study.
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- Progressive supranuclear palsy (PSP) is a neurodegenerative disease classified into different phenotypes, mainly PSP with Richardson's syndrome (PSP-RS) and PSP with predominant parkinsonism (PSP-P), based on clinical features.
- The study aimed to analyze how speech disorders, particularly dysarthria, manifest differently in PSP-RS and PSP-P patients, with both groups showing similar demographics and disease severity.
- Results indicated no significant differences in speech profiles between the two subtypes at mid-stage disease, though PSP-RS patients exhibited greater impairment in oculomotor function.
Background: Dystonia presents a growing concern based on evolving prevalence insights. Previous research found that, in cervical dystonia, high-frequency repetitive somatosensory stimulation (RSS; HF-RSS) applied on digital nerves paradoxically diminishes sensorimotor inhibitory mechanisms, whereas low-frequency RSS (LF-RSS) increases them. However, direct testing on affected body parts was not conducted.
View Article and Find Full Text PDFBackground: Midline Tremor is defined as an isolated or combined tremor that affects the neck, trunk, jaw, tongue, and/or voice and could be part of Essential Tremor (ET), or dystonic tremor. The clinical efficacy of deep brain stimulation for Midline Tremor has been rarely reported. The Ventral Intermediate Nucleus and Globus Pallidus Internus are the preferred targets, but with variable outcomes.
View Article and Find Full Text PDFBackground: Hemiballism (HB) and hemichorea (HC) are the most frequent secondary movement disorders, usually caused by cerebrovascular diseases. In only a minority of cases, these involuntary movements are not self-limited, and they may severely compromise patients' quality of life, so that symptomatic treatments are required. Typical and atypical neuroleptics as well as tetrabenazine are considered therapies of choice.
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