Differences between gastric antiulcer effects of trapencaine enantiomers.

The spatial arrangement of single stereoisomers may influence pharmacodynamic, pharmacokinetic and toxicological properties of a drug. Trapencaine (I. N.

[Drug chirality].

Chirality is a stereochemical phenomenon in the area of drugs, influencing pharmacodynamic, pharmacokinetic, and biotransformation processes. On an example of known drugs, the present paper describes the relations of chirality to drug efficacy, safety, toxicity, manifestations of drug interactions, and some other factors with a feedback action on the chirality-drug relationship.