Identifying the Molecular Fingerprint of Beta-Lactams via Raman/SERS Spectroscopy Using Unconventional Nanoparticles for Antimicrobial Stewardship.

Beta-lactam antibiotics, derived from penicillin, are the most used class of antimicrobials used for treating bacterial infections. Over the years, microorganisms have developed resistance mechanisms capable of preventing the effect of these drugs. This condition has been a significant public health concern for the 21st century, especially after predictions that antimicrobial resistance could lead to 10 million deaths annually by 2050.

Differences in 5-km running pace between female and male triathletes.

During an IRONMAN, the pacing strategy in the running segment differs significantly between sexes. However, it is unknown if sex affects the running pace in shorter triathlon events. This study compared the pacing strategy between sexes during a 5-km running test performed following a 20-km cycle (sprint triathlon distances).

Cycling Intensity Effect on Running Plus Cycling Performance among Triathletes.

Running performance is crucial for triathlon performance. However, the prior bout of cycling may affect the running split time. This study compared the triathletes' cycling plus running (C+R) time, when cycling was performed at three different intensities and running was maximal.

Olfactory receptor coexpression and co-option in the dengue mosquito.

The olfactory sensory neurons of vinegar flies and mice tend to express a single ligand-specific receptor. While this 'one neuron-one receptor' motif has long been expected to apply broadly across insects, recent evidence suggests it may not extend to mosquitoes. We sequenced and analyzed the transcriptomes of 46,000 neurons from antennae of the dengue mosquito to resolve all olfactory, thermosensory, and hygrosensory neuron subtypes and identify the receptors expressed therein.

Exploring the Logic and Conducting a Comprehensive Evaluation of the Adiponectin Receptor Agonists AdipoRon and AdipoAI's Impacts on Bone Metabolism and Repair-A Systematic Review.

Introduction: Adiponectin replacement therapy shows promising outcomes in various diseases, especially for bone-related disorders. Challenges in using the complete protein have led to alternative approaches, with AdipoRon and AdipoAI emerging as extensively researched drug candidates. Their influence on models of bone-related disorders has progressed considerably but there has been no review of their effectiveness in modulating bone metabolism and repair.