Publications by authors named "V Reuter"
Article Synopsis
- - Gain-of-function mutations in isocitrate dehydrogenase (IDH) are critical in various cancers and can be targeted in cholangiocarcinoma, low-grade glioma, and acute myeloid leukemia, with rare mutations found in prostate cancer (PCa).
- - A study analyzed two cohorts of PCa cases for IDH mutations, identifying 0.4% in cohort 1 and 0.3% in cohort 2, with a notable correlation between IDH1 hotspot mutations and higher-grade disease accompanied by specific calcifications.
- - The research revealed that PCa cases with IDH1 hotspot mutations lacked common genetic alterations typically associated with more aggressive cancer types, indicating that IDH1 mutations may play
Article Synopsis
- - Oncocytic renal neoplasms pose significant diagnostic challenges, yet are generally nonaggressive, prompting discussion about the necessity of differentiating emerging subtypes like eosinophilic solid and cystic renal cell carcinoma and others.
- - A survey of 63 urologic pathologists revealed that many encounter complex oncocytic tumors frequently, with 70% agreeing that eosinophilic solid and cystic renal cell carcinoma should be recognized as a distinct category, while opinions were more divided on other types.
- - Diagnostic approaches varied among pathologists, with 60% hesitant to diagnose oncocytoma through needle biopsies, and a near split on the routine use of immunohistochemistry; common genetic testing was
Background: During active surveillance (AS) for Grade Group (GG) 2 prostate cancer, pathologic progression to GG3 on surveillance biopsy is a trigger for intervention. However, this ratio of GP3:GP4, may be obscured by increases of relatively indolent disease. We aimed to explore changes in GP4 quantity during AS and propose alternative definitions for progression based on GP4 changes.
View Article and Find Full Text PDFObjective: To review the presentation and long-term oncologic outcomes of patients with regressed ("burnt out") primary testicular germ cell tumors (GCT). Certain testicular GCT can present with complete regression of the primary tumor. It is not well established if this is associated with more aggressive disease or worse oncologic outcomes.
View Article and Find Full Text PDFArticle Synopsis
- * The survey received an 85% response rate from 98 uropathologists, revealing strong agreement on distinguishing between luminal and basal UC types, but varied opinions on the importance of certain genetic tests like FGFR3 and TERT promoter mutations.
- * Most uropathologists acknowledged the aggressive nature of tumors with micropapillary features and favored further evaluation and specific molecular testing for aggressive subtypes, indicating a need for improved consensus in UC classification and treatment strategies.