Publications by authors named "V Ravi Chandran"
Absence of functional acid-α-glucosidase (GAA) leads to early-onset Pompe disease with cardiorespiratory and neuromuscular failure. A novel Pompe rat model ( ) was used to test the hypothesis that neonatal gene therapy with adeno-associated virus serotype 9 (AAV9) restores cardiorespiratory neuromuscular function across the lifespan. Temporal vein administration of AAV9-DES-GAA or sham (saline) injection was done on post-natal day 1; rats were studied at 6-12 months old.
View Article and Find Full Text PDFRhino-orbital-cerebral mucormycosis (ROCM) is an opportunistic infection that has increased due to COVID-19 with the use of corticosteroids and diabetes being the most important predisposing factors. Orbital apex syndrome with central retinal artery occlusion secondary to mucormycosis is relatively rare. This case report highlights a case of a 62-year-old female with poorly controlled diabetes and a history of COVID-19 two weeks prior, who presented with acute right eye painful visual loss for three days associated with bulging of the right eye and drooping of the eyelid.
View Article and Find Full Text PDFObjectives: Diabetes mellitus (DM) is among the four noncommunicable diseases. There are two types-type I and type II. The prevalence of type I DM in India is 0.
View Article and Find Full Text PDFArticle Synopsis
- * Key risk factors for developing CKD include diabetes, kidney stones, joint damage, high uric acid levels, and daily NSAID use; however, methotrexate appears to have a protective effect against CKD.
- * The study highlights the importance of monitoring renal outcomes in PsA patients, considering these associated risks and the long-term implications of CKD.
Background: Exercise can be used as a model to understand immunometabolism. Biological data on elite athletes are limited, especially for female athletes, including relevant data on acute-phase proteins and amino acid metabolism.
Methods: We analyzed acute-phase proteins and amino acids collected at South American, Pan-American, and Olympic Games for 16 Olympic sports.