Publications by authors named "V Ratanatharathorn"
Involvement of lower gastrointestinal tract (LGI) occurs in 60% of patients with graft-versus-host-disease (GVHD). Complement components C3 and C5 are involved in GVHD pathogenesis. In this phase 2a study, we evaluated the safety and efficacy of ALXN1007, a monoclonal antibody against C5a, in patients with newly diagnosed LGI acute GVHD receiving concomitant corticosteroid.
View Article and Find Full Text PDFTotal-body irradiation (TBI)-based conditioning regimen is preferred in acute lymphoblastic leukemia (ALL). We retrospectively evaluated allogeneic stem cell transplant (alloSCT) outcomes of 86 adult ALL patients in complete remission (CR) who received TBI-containing reduced intensity (RIC) (Flu/Mel/TBI = 31) and myeloablative conditioning (MAC) (VP16/TBI = 47; CY/TBI = 8) between January 2005 and December 2019. All patients received peripheral blood allografts.
View Article and Find Full Text PDFThree-Year Outcomes in Recipients of Mismatched Unrelated Bone Marrow Donor Transplants Using Post-Transplantation Cyclophosphamide: Follow-Up from a National Marrow Donor Program-Sponsored Prospective Clinical Trial.
Transplant Cell Ther
March 2023
Article Synopsis
- * A clinical trial involving 80 patients treated with either myeloablative or reduced-intensity conditioning demonstrated a 3-year overall survival rate of 70% for the reduced-intensity group and 62% for the myeloablative group, with no reported GVHD after one year.
- * The findings highlight the potential benefits of PTCy in mismatched unrelated donor HCT, though further research is needed to address issues like relapse rates and optimal donor