Publications by authors named "V Ranjit N Munasinghe"

This paper has two concurrent goals. On one hand, we hope it will serve as a simple primer in the use of linear mixed modelling (LMM) for inferential statistical analysis of multimodal data. We describe how LMM can be easily adopted for the identification of trial-wise relationships between disparate measures and provide a brief cookbook for assessing the suitability of LMM in your analyses.

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Information can be encoded and stored in sequences of monomer units organized in linear synthetic polymers. Replication of sequence information is of fundamental importance in biology; however, it represents a challenge for synthetic polymer chemistry. A combination of covalent and noncovalent base pairs has been used to achieve high-fidelity templated synthesis of synthetic polymers that encode information as a sequence of different side-chain recognition units.

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Article Synopsis
  • The study presents a unique type of rotaxane host system designed to selectively bind lithium chloride ion-pair species, demonstrating a mechanism where lithium cation binding simultaneously increases the affinity for halide anions.
  • The rotaxane consists of a macrocycle with specific binding sites for both cations and anions, and an axle that can enhance these interactions through either halogen or hydrogen bonding.
  • Experimental techniques like H NMR titration and X-ray crystallography were employed to confirm that this rotaxane design shows a clear preference for binding lithium halides over sodium or potassium halides, particularly highlighting the selectivity for lithium chloride.
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Little is known about the life cycle and mode of transmission of . Recently it was suggested that fecal–oral transmission of cysts may play a role in the transmission of . In order to establish an infection, is required to remain viable when exposed to the pH of the stomach.

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A family of novel halogen bonding (XB) and hydrogen bonding (HB) heteroditopic [2]rotaxane host systems constructed by active metal template (AMT) methodology, were studied for their ability to cooperatively recognise lithium halide (LiX) ion-pairs. H NMR ion-pair titration experiments in CD CN:CDCl solvent mixtures revealed a notable "switch-on" of halide anion binding in the presence of a co-bound lithium cation, with rotaxane hosts demonstrating selectivity for LiBr over LiI. The strength of halide binding was shown to greatly increase with increasing number of halogen bond donors integrated into the interlocked cavity, where an all-XB rotaxane was found to be the most potent host for LiBr.

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