Synchronous Aberration of the Jugular and Carotid-a Case Report.

Vascular aberrations in the head and neck region pose a grave diagnostic and a surgical challenge. Numerous reports in the literature have highlighted the incidence and the lethality associated with carotid or jugular anomalies signifying the need for awareness and preparedness by the clinicians while treating patients. Our paper reports a peculiar case showing asymptomatic double vessel aberration in relation to the internal jugular vein as an ectasia and carotid kinking in the same patient diagnosed with oral carcinoma.

Comprehensive stable-isotope tracing of glucose and amino acids identifies metabolic by-products and their sources in CHO cell culture.

Mammalian cell culture processes are widely utilized for biotherapeutics production, disease diagnostics, and biosensors, and hence, should be optimized to support robust cell growth and viability. However, toxic by-products accumulate in cultures due to inefficiencies in metabolic activities and nutrient utilization. In this study, we applied comprehensive C stable-isotope tracing of amino acids and glucose to two Immunoglobulin G (IgG) producing Chinese Hamster Ovary (CHO) cell lines to identify secreted by-products and trace their origins.

Three doses of COVID-19 mRNA vaccine induce class-switched antibody responses in inflammatory arthritis patients on immunomodulatory therapies.

Patients with inflammatory arthritis (IA) are at increased risk of severe COVID-19 due to medication-induced immunosuppression that impairs host defenses. The aim of this study was to assess antibody and B cell responses to COVID-19 mRNA vaccination in IA patients receiving immunomodulatory therapies. Adults with IA were enrolled through the Johns Hopkins Arthritis Center and compared with healthy controls (HC).

Investigating the Medical Aspects of the World's Worst Industrial Disaster.

The 1984 disaster in Bhopal, India caused much mortality and morbidity of a multisystemic nature in the exposed population. Heated scientific debates occurred about the spectrum of health effects, toxicology, and treatment. The national and transnational aspects of the disaster impeded scientific public health investigation.