Publications by authors named "V Rajathi"
Benzylidene-isophorone hybrids with strong anticancer activity.
Spectrochim Acta A Mol Biomol Spectrosc
October 2024
Isophorone is a cyclic ketone that has gained significant attention in the field of organic chemistry due to its versatile reactivity and structural attributes. Derivatives of isophorone offer a broad spectrum of applications ranging from pharmaceuticals to polymer chemistry. With the aim of developing novel hybrid structures based on benzylidene by combining with isophorone scaffold, we report 3 derivatives of the benzylidene-isophorone hybrids and its potent anticancer activity.
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- Acquired epilepsies begin after a brain injury, leading to the gradual development of seizures, but the processes behind this progression (epileptogenesis) are not fully understood; microRNAs like miR-324-5p have been linked to regulating these processes.
- In a study with mice, researchers tested the effects of inhibiting miR-324-5p during the epileptogenesis phase by using a specific model (IHpKa) and monitoring through EEG for 28 days.
- The findings showed that inhibiting miR-324-5p did not prevent the onset or severity of seizures but did affect certain EEG activity patterns, suggesting that timing of treatment is crucial and that miR-324-5
About one-third of individuals living with epilepsy have treatment-resistant seizures. Alternative therapeutic strategies are thus urgently needed. One potential novel treatment target is miRNA-induced silencing, which is differentially regulated in epilepsy.
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