Publications by authors named "V R Roth"
Background: Spinocerebellar ataxia 27B is the most common genetic late onset cerebellar ataxia (LOCA). However, it commonly overlaps with other genetic LOCA as with the cerebellar form of multiple system atrophy (MSA-C).
Objectives: To pinpoint which clinical signs and symptoms best discriminate between FGF14 + from FGF14 - patients at symptoms' onset.
Article Synopsis
- The study explores using a new formulation, High hypericin-loaded polyvinylpyrrolidone (HHL-PVP), to enhance the diagnosis and treatment of brain tumors, specifically glioblastomas, through fluorescence imaging.
- Researchers tested a CMOS camera system with specific filters to differentiate hypericin from a common dye (5-ALA) used in brain surgery, successfully demonstrating the ability to visualize hypericin in tumor tissues.
- Results showed that HHL-PVP significantly increased fluorescence intensity and lifetime, indicating high diagnostic sensitivity (87.5%) and perfect specificity (100%) for identifying treated glioblastoma specimens, suggesting potential for future clinical applications.
Platinum (Pt) nanoparticles are widely used as catalysts in proton exchange membrane fuel cells. In recent decades, sputter deposition onto liquid substrates has emerged as a potential alternative for nanoparticle synthesis, offering a synthesis process free of contaminant oxygen, capping agents, and chemical precursors. Here, we present a method for the synthesis of supported nanoparticles based on magnetron sputtering onto liquid poly(ethylene glycol) (PEG) combined with a heat-treatment step for attachment of nanoparticles to a carbon support.
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- The study investigates the factors affecting the expansion of tandem repeats, focusing on the FGF14 (GAA)·(TTC) repeat locus in a large sample of 2,530 individuals through advanced sequencing techniques.
- Researchers discovered a prevalent 5'-flanking variant present in over 70% of alleles, which is linked to nonpathogenic alleles and the ancestral lineage of this genetic marker.
- This common variant is associated with greater stability of the tandem repeat during inheritance and improved accessibility of chromatin, suggesting a role in preventing pathological expansion.