Publications by authors named "V R Paixao-Cortes"
The identification of thalidomide-Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain. The aim of this study was to detect sequence divergences between species, affected or not by TE, and to evaluate the regulated gene co-expression in a murine model.
View Article and Find Full Text PDFArticle Synopsis
- * The intracellular domain of the PRL receptor (PRLR-ICD) plays a key role in regulating the PRLR gene's expression, with differences noted between eutherian and metatherian mammals but many conserved aspects across mammals.
- * Some specific genetic changes in PRLR-ICD, especially in primates, show signs of selection, suggesting these motifs may contribute to unique adaptations without disrupting the hormone's fundamental roles.
Objectives: MicroRNAs (miRNAs) play an important regulatory role in the expression of genes involved in brain functions during development. Genetic variants in miRNA genes may impact their regulatory function and lead to psychiatric disorders. To evaluate the role of genetic variants in genes of miRNAs differentially expressed during neurodevelopment on autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), schizophrenia (SCZ), and major depressive disorder (MDD).
View Article and Find Full Text PDFThe purpose of this study is to evaluate the effects of Methylphenidate exposure on mice odontogenesis and connect them by bioinformatics with human odontogenesis. Thirty-two pregnant Swiss mice were divided into treated group and control group, which received, respectively, 5 mg/kg of Methylphenidate and saline solution from the 5th to the 17th day of pregnancy. The mouse embryos tooth germs were analyzed through optical microscopy, and the data collected were analyzed statistically by Fisher's exact test.
View Article and Find Full Text PDFArticle Synopsis
- Scientists are still learning about the Zika virus and its effects since we don't know everything even after many studies since 2015.
- Musashi 1 (MSI1) is a special protein that helps nerve development and also helps the Zika virus make copies of itself.
- Research shows that different variations of MSI1 can affect how well the Zika virus can infect cells, suggesting that some versions of MSI1 might not work well with the virus.